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- Ce n'est pas à la nature de produire comme nos usines. C'est à nos usines de produire comme la nature !
- ScienceDirect.com | Science, health and medical journals, full text articles
- A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia
- Inhibition of NOS- like activity in maize alters the expression of genes
- Retour la nature pour nos sapins de Noel
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- Dictionnaire, definitions, section_expression, conjugaison, synonymes, homonymes, difficultes, citations.notre - Definitions Francais : Retrouvez la définition de notreThe intervention include eight lesson plan (16?hours) The 1st ? 7th lesson plan allowed students to learn science based on inquiry cycle (5Es) with reflected the learning activity they done to clarify the issues related to the nature of science.Participants? concept of NOS and attitudes toward teaching was examined through adapted version of VOSE questionnaire after the invention.The 8th lesson plan, the activity of puzzling box allowed student teachers to come explicitly up with the nature of science. or its licensors or contributors.Previous article in issue Next article in issue Keywords Nature of Science Inquiry Cycle 5E graduate students Download full text in PDF Recommended articles Citing articles (0).The participants were the first year master degree students in science education program who enrolled in 232711 history and philosophy in science, academic year of 2010.ScienceDirect ? is a registered trademark of Elsevier B.Copyright ? 2020 Elsevier B.By continuing you agree to the use of cookies.
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Concepts of Nature of Science.
The sample was not screened for psychiatric disorders; however, all subjects were free of medication, and the study was explained to them, so that the likelihood that severe psychiatric disorders, especially chronic SCZ, present in the control sample was low.Yet NOS-I is not only a part of the glutamatergic system, but also influences the serotonergic and dopaminergic tone in the brain by modulating monoamine transporter function.This may have been due to a range of problems: ethnic stratification, broad phenotype definition (thus, we chose to restrict the SCZ phenotype in our study to severely ill, non-remitting cases) or restriction to one, often non-functional SNP. VNTR1 SS, LS and LL), univariate ANOVAs were applied, followed by post hoc t -tests if indicated.e.Thus, NO is a promising candidate molecule in the pathogenesis of endogenous psychoses and a potential target in their treatment. The Nature of Science.
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However, in view of the fact that CAT is also involved in the catalytic detoxification of excess H 2 O 2 in plant cells 15, it is important to investigate if inhibition of NOS-like activity may influence CAT enzymatic activity.The first oxidation step is catalyzed by choline monooxygenase (CMO, EC 1.Full size image Figure 3 Expression of maize ascorbate peroxidase (APX) genes APX6 ( A ), APX4 ( B ), APX3 ( C ) and APX1.In plants treated with the nitric oxide synthase inhibitor, the transcript levels of ascorbate peroxidase-encoding genes were down-regulated.This, however, does not exclude the possibility of post-translational regulation of BADH proteins by such mechanisms as S-nitrosylation.The catalase reaction was initiated by addition of 30 mM H 2 O 2 and absorbance was measured immediately. NOS knockouts and neuroprotection.
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) of nature of science, are critical and developmentally appropriate (for precollege students).Dordrecht, The Netherlands: Springer Publishing. 1982.Other shared elements include observations, rational argument, inference, skepticism, peer review, and reproducibility of the work.Although objectivity is always desired in the interpretation of data, some subjectivity is unavoidable and often beneficial (Chalmers 1999; Gould 1981; Laudan 1977). “Explicit” does not mean that the teacher should lecture about NOS.Chicago: University of Chicago Press 59: 113.Cambridge, MA: Harvard University Press.Rather, it refers to reflective discussions among students about the science concepts they are learning (Clough 2011).Queensland, AU: University of Queensland Press.It is not learned by chance, simply by doing science.With new evidence and interpretation, old ideas are replaced or supplemented by newer ones.All too often, NOS is only taught explicitly at the beginning of a science course, independent of any of the science content that will subsequently follow.
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Nitric oxide (NO) is a gaseous neurotransmitter thought to play important roles in several behavioral domains. On a neurobiological level, NO acts as the second messenger of the N-methyl-D-aspartate receptor and interacts with both the dopaminergic as well as the serotonergic system. Thus, NO is a promising candidate molecule in the pathogenesis of endogenous psychoses and a potential target in their treatment. Furthermore, the chromosomal locus of the gene for the NO-producing enzyme NOS-I, 12q24.2, represents a major linkage hot spot for schizophrenic and bipolar disorder. To investigate whether the gene encoding NOS-I (NOS1) conveys to the genetic risk for those diseases, five NOS1 polymorphisms as well as a NOS1 mini-haplotype, consisting of two functional polymorphisms located in the transcriptional control region of NOS1, were examined in 195 chronic schizophrenic, 72 bipolar-I patients and 286 controls. Single-marker association analysis showed that the exon 1c promoter polymorphism was linked to schizophrenia (SCZ), whereas synonymous coding region polymorphisms were not associated with disease. Long promoter alleles of the repeat polymorphism were associated with less severe psychopathology. Analysis of the mini-haplotype also revealed a significant association with SCZ. Mutational screening did not detect novel exonic polymorphisms in patients, suggesting that regulatory rather than coding variants convey the genetic risk on psychosis. Finally, promoter polymorphisms impacted on prefrontal functioning as assessed by neuropsychological testing and electrophysiological parameters elicited by a Go-Nogo paradigm in 48 patients (continuous performance test). Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning..
Nitric oxide synthase-like activity contributes to the production of nitric oxide in plants, which controls plant responses to stress. This study investigates if changes in ascorbate peroxidase enzymatic activity and glycine betaine content in response to inhibition of nitric oxide synthase-like activity are associated with transcriptional regulation by analyzing transcript levels of genes (betaine aldehyde dehydrogenase) involved in glycine betaine biosynthesis and those encoding antioxidant enzymes (ascorbate peroxidase and catalase) in leaves of maize seedlings treated with an inhibitor of nitric oxide synthase-like activity. In seedlings treated with a nitric oxide synthase inhibitor, transcript levels of betaine aldehyde dehydrogenase were decreased. In plants treated with the nitric oxide synthase inhibitor, the transcript levels of ascorbate peroxidase-encoding genes were down-regulated. We thus conclude that inhibition of nitric oxide synthase-like activity suppresses the expression of ascorbate peroxidase and betaine aldehyde dehydrogenase genes in maize leaves. Furthermore, catalase activity was suppressed in leaves of plants treated with nitric oxide synthase inhibitor; and this corresponded with the suppression of the expression of catalase genes. We further conclude that inhibition of nitric oxide synthase-like activity, which suppresses ascorbate peroxidase and catalase enzymatic activities, results in increased H2O2 content.